Effect of redox potential and pH status on degradation and adsorption behavior of tylosin in dairy lagoon sediment suspension

Abstract

Veterinary antibiotics are the most heavily used pharmaceuticals in intensive animal farming operation. Their presence in the environment through application of manure and lagoon water as fertilizer in agricultural fields has generated a growing concern in recent years due to potential threat to the ecosystem and the risk they pose to human and animal health. Among the antibiotics, tylosin, a macrolide class of antibiotics, has been widely used for disease prevention and growth promotion in swine, cattle/dairy, and poultry production. To understand degradation and sorption behavior of tylosin A, a laboratory microcosm incubation study was conducted on dairy lagoon sediments suspension under different pH (5.5, 7.0, 8.5) and redox potentials (Eh at −100mV, 0mV, +250mV, +350mV). Sorption and degradation of tylosin was strongly influenced by sediment pH and redox conditions. Under acidic (pH 5.5) and reduced (Eh −100mV) condition, tylosin persisted in the solution phase of dairy lagoon sediment suspension much longer with resident time of 77d. Under oxidized (Eh +350mV) condition, microbial degradation was much greater causing 68–75% of tylosin loss from the solution at pH 5.5 and 32–75% at pH 7.0 during the 20d incubation. At pH 8.5, abiotic transformation of tylosin A into unknown degradates rather than sediment adsorption and microbial degradation was the major mechanism controlling tylosin disappearance from the solution regardless of the status of redox potentials. Overall, the results suggested that under reduced condition with low pH, tylosin will be persisted in the lagoon effluents and residue of tylosin may enter agricultural fields through the application of lagoon slurry as fertilizer.