Abstract
Background: Diabetes mellitus is a growing metabolic disorder at a fast rate throughout the world, and it is the 16th leading cause of global mortality. The significant anti-dyslipidemic effect of red Hibiscus extract may be safe and better alternative available over other agents in diabetic-associated dyslipidemia. Objective: Demonstrating the antioxidant property of Hibiscus in the role of reduction of blood glucose level. Material and Methods: Sixty adult male albino rats were used in this study. The rats were divided into six equal groups, i.e. control, alloxan-treated, hot red Hibiscus extract- treated cold red Hibiscus extract-treated, alloxan-treated plus hot red Hibiscus extract- treated and alloxan-treated plus cold red Hibiscus extract-treated groups. Blood samples were obtained for determination of serum glucose, insulin, total cholesterol, triglycerides, HDL- cholesterol, LDL-cholesterol as well as histopathological changes of the pancreas. Results: Treatment with red Hibiscus (hot and cold) extract was found to be effective in ameliorating lipid profile, blood glucose and insulin levels. Conclusion: The hypoglycemic, hypolipidemic and antioxidant properties of red Hibiscus were valuable in treatment of diabetes mellitus, and great consideration should be taken toward the use of Hibiscus as a complementary therapy beside ordinary anti-diabetic and hypolipidemic drugs.
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