Abstract
Newcastle disease virus (NDV) has been reported to selectively duplicate in and then destroy tumor cells, whilst sparing normal cells. However, the effect of NDV on lung cancer has yet to be elucidated. In the present study, recombinant NDV (rl-RVG) was applied to lung adenocarcinoma A549 cell tumor-bearing mice to explore its effect on the proliferation of the cells and the immune response of the mice. Following rl-RVG transfection, RVG and NDV gene expression, decreased tumor growth, subcutaneous tumor necrosis, tumor apoptosis and an increased number of cluster of differentiation (CD)3−/CD49+ natural killer cells were more evident in the rl-RVG group. The present study demonstrated that rl-RVG transfection effectively restrained lung adenocarcinoma A549 cell growth in vivo, which may have been accomplish by inducing tumor cell apoptosis and regulating the cell immune response.
Highlights
Worldwide, lung cancer is the main cause of cancer mortality
In the rl‐Rabies virus glycoprotein (RVG) and Newcastle disease virus (NDV) groups, the volumes were markedly smaller at day 21 compared with those detected in the phosphate‐buffered saline (PBS) group (P
The results revealed that tumor cells from the rl‐RVG group underwent the most destructive necrosis, while necrosis was not observed in the PBS group
Summary
Lung cancer is the main cause of cancer mortality. Despite the aggressive treatment methods that have been adopted in the past decades, including radiotherapy, chemotherapy and surgery, the five‐year survival rate of lung cancer patients remains low.As one of the novel therapeutic approaches to cancer, oncolytic viral treatments possess great potential. Lung cancer is the main cause of cancer mortality. Despite the aggressive treatment methods that have been adopted in the past decades, including radiotherapy, chemotherapy and surgery, the five‐year survival rate of lung cancer patients remains low. As one of the novel therapeutic approaches to cancer, oncolytic viral treatments possess great potential. It has been found that a variety of viruses possess tumor‐oncolytic effects [1]. Newcastle disease virus (NDV) is among these oncolytic viruses and has been regarded as a promising oncolytic agent that has been used in experimental clinical therapy for >40 years [2]
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