Effect of real-time continuous monitoring system on serum inflammatory factors and prognosis in patients with sepsis

Abstract

Objective To investigate the effect of real-time continuous monitoring system (RT-CGMS) on serum inflammatory factors and prognosis in patients with sepsis. Methods According to the prospective studies, patients were randomly divided into two groups Patients with sepsis were randomly divided into real-time continuous monitoring of blood glucose group and monitoring blood glucose meter group, of which the fasting serum tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) and high sensitive C reactive protein (hs-CRP) were detected on the 1st, 3rd, 7th day. Meanwhile, insulin dosage, incidence of hypoglycemia and mortality rate of 28 days of patients in two groups were recorded, and the above indexes were analyzed. Results TNF-α, IL-6 and hs-CRP in the real-time continuous blood glucose monitoring group were (16.12±2.42) pg/ml、(112.37±17.39) pg/ml and (19.62±2.72) mg/L on the 7th day respectively, while TNF-α, IL-6 and hs-CRP in the blood glucose monitoring group were (23.46±3.12) pg/ml、(140.19±21.48) pg/ml and (25.42±2.54) mg/L on the 7th day, respectively. The decrease of TNF-α, IL-6 and hs-CRP in the continuous blood glucose monitoring group was more significant than that in the blood glucose monitoring group (P<0.05) . Insulin dosage in real-time continuous blood glucose monitoring group was (90.62±15.79) u, hypoglycemia rate was 5.4%, fatality rate was 10.81% in 28 days of hospitalization, insulin dosage was (130.59±20.65) u, hypoglycemia rate was 22.85%, and fatality rate was 31.42% in 28 days of hospitalization. There was significant difference between the two groups (P<0.05) . Conclusion For sepsis patients with stress hyperglycemia, a real-time continuous monitoring system combined with insulin therapy can improve the inflammatory response, and control blood glucose effectively as well as reduce mortality. Key words: Real-time continuous monitoring system; Sepsis; Inflammatory factors