Abstract
Background: Radiation therapy has proven to be an effective modality in treating children suffering from cancer. High prevalence of dental caries is seen in children undergoing radiation therapy. This is primarily due to the direct effects of these harmful radiation on the enamel and not as a consequence to the reduced salivary flow. Mechanical properties of the enamel have been seen to be affected by radiation according to various studies conducted.
 Objectives: The objective of this study is to evaluate whether radiotherapy causes changes in the microhardness and surface morphology of enamel in primary teeth pretreated with silver diamine fluoride.
 Methodology: 22 primary teeth samples will be divided into two groups, 11 samples each-study group which will be pretreated with silver diamine fluoride (SDF) and control group. Both groups will be subjected to radiotherapy of 10 Gy radiation for a duration of 6 days. The samples will be tested for Vickers microhardness test and SEM analysis for surface morphological changes post radiotherapy. Statistical analysis will be done using “chi square test, paired and unpaired student t -test”. Surface microhardness and morphological changes of the study and control group compared.
 Expected Results: It is expected that SDF application will be effective modality in prevention of caries due to frequent radiation exposure in children suffering from cancer and undergoing radiotherapy.
 Conclusion: The study will conclude that SDF will cause a reduction in the microhardness of the surface and lesser morphological changes in the enamel of the primary teeth post radiation therapy in children suffering from cancer.
Highlights
Cancer is one of the deadliest diseases known to mankind resulting in around 4 lakh children being diagnosed each year, of which a large number around the globe do not have proper access to health care [1].Radiation therapy has been used extensively in the field of medicine, for the treatment of various kinds of cancers but its margin of safety is still low
Expected Results: It is expected that silver diamine fluoride (SDF) application will be effective modality in prevention of caries due to frequent radiation exposure in children suffering from cancer and undergoing radiotherapy
Specimens will be divided into two groups: 1. Study group: Deciduous teeth pretreated with SDF
Summary
Cancer is one of the deadliest diseases known to mankind resulting in around 4 lakh children being diagnosed each year, of which a large number around the globe do not have proper access to health care [1]. Various studies have proved that there is destruction of the prismatic structure of enamel, decrease in mechanical properties such as tensile strength, wear resistance, and acid attack resistance all these changes have been seen in the permanent teeth of patients who have undergone radiation therapy [3]. Primary teeth when compared to permanent teeth have thinner and higher density of rods, large number of microporosities, exposed rods in some areas, and a lot of carbonate addition. All these factors make primary teeth more susceptible to radiation caries and more extensive carious lesions [2,4,5]. Aim: To evaluate the effect of radiotherapy on microhardness and surface morphology of pretreated primary teeth with silver diamine fluoride
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