Effect of radiation emitted from mobile phone on bone marrow haematopoietic stem cell in mice

Abstract

The present research aims to explore the potential impact of mobile phone radiation on bone marrow haematopoietic stem cell in mice. 160 male BALB/C mice aged 3–4 weeks were randomly distributed into 4 groups as blank control, control, TD-SCDMA and LTE-Advanced respectively, with 40 mice in each group. Mice were designed to receive cell phone radiation for 2–8 weeks. 10 mice in each group were taken out for examinations given radiation exposure periods were 2, 4, 6 and 8 weeks respectively. Then terminal deoxynuclotidyl transferase-mediated dUTP Nick-end labelling technique was conducted to detect the apoptosis of stem cell, and morphological method was carried out for the examination of micronucleus and subpopulations of bone marrow haematopoietic stem cell, while enzyme immune technique was performed to analyse the subsets of T lymphocyte. As a result, no statistical differences were discovered on issues of apoptosis and micronucleus during the entire experimental period in the 2 sham radiation control groups. Notwithstanding similar results were seen in TD-SCDMA and LTE-Advanced groups after exposed to radiation for 2 or 4 weeks, apoptosis began to be enhanced and micronucleus to be increased given the mice experience longer exposure as 6 or 8 weeks. There were virtually negligible effects on subpopulations of stem cell, as well as on subsets of T lymphocyte of peripheral blood during the entire experimental period in the 4 groups. It could be concluded that long-term radiation from cell phone could induce apoptosis of haematopoietic stem cell in mice; moreover, it seems to stimulate the formation of micronucleus, yet with even negligible effect on the proportions of stem cell subpopulations and peripheral blood T lymphocyte subsets.