Effect of racecadotril granules combined with paediatric amino acid on infant rotavirus enteritis

Abstract

Objective To observe the effect of racecadotril granules combined with paediatric amino acid on infant rotavirus enteritis.Methods One hundred and forty children with rotavirus enteritis were randomly divided into treatment group and control group,with 70 cases in each group.Control group was given comprehensive treatment,such as fluid taken,intestinal microecdogical balance mainten ance and gastrointestinal mucous protection; treatment group was treated with racecadotril granules and paediatric amino acid on the basis of above treatment.The body temperature,the change of defecation frequency and character,the total effective rate,the time of checking diarrhea and total course of the two groups were observed.Results The time of checking diarrhea and total course in the treatment group was (2.2 ± 0.6) d,(5.2 ± 1.3) d,and (3.9 ± 2.3) d,(7.0 ± 1.9) d in the control group,the differences were significant between the two groups (P ＜ 0.05).The obvious effective rate and total effective rate in the treatment group was 55.8％,88.3％,and 31.4％,70.0％ in the control group,the differences were significant between the two groups (P ＜ 0.05).Conclusions Racecadotril granules and paediatric amino acid in the treatment of infant rotavirus enteritis is safe and effective,which can alleviate the symptoms quickly,shorten the course,reduce or avoid the growth retardation caused by diarrhea,and is helpful to children growth. Key words: Racecadotril granules ; Paediatric amino acid ; Rotavirus ; Enteritis