Abstract

Kidney stone or Urolithiasis is a solid particle that forms in the urinary tract. In Morocco, as in many countries, most patients use medicinal plants as an alternative therapy for many diseases, including lithiasis. The fruit of Cydonia oblonga Miller. is traditionally used for the prevention and treatment of several diseases. The present study aims to explore the effects of aqueous extracts of pulp and peel quince on oxalocalcic crystallization. These results show that the aqueous extracts of C. oblonga M can inhibit calcium oxalate crystallization.

Highlights

  • Urinary calculi affect a large part of the population, it is evident that urine supersaturation is an important factor in the formation of these urinary concretions

  • Calcium oxalate monohydrate (COM) or Whewellite (CaC2O4.H2O), calcium oxalate dihydrate (COD) or Weddellite (CaC2O4.2H2O), and calcium oxalate trihydrate (COT) or CaOxite (CaC2O4.2H2O) are three forms of hydrated calcium oxalates, which can present in urinary stones [3]

  • We report the effects of aqueous extracts of quince fruit on experimental calcium oxalate crystals

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Summary

Introduction

Urinary calculi affect a large part of the population, it is evident that urine supersaturation is an important factor in the formation of these urinary concretions. Kidney stones are composed of calcium salts, uric acid, cystine and struvite, depending on the main etiological entity. Approximately 70% of human urinary stones contain calcium phosphate and calcium oxalate. Urine contains many molecules able to inhibit crystallization. Dietary factors appear to have an effect on the ability of urine to inhibit calcium oxalate crystallization[1]. The potential use of natural substances to inhibit crystallization is more widespread, we tested the inhibitory effects of Cydonia oblonga Miller., the common Quince, belonging to the Rosaceae family, genus Cydonia[4]. We report the effects of aqueous extracts of quince fruit on experimental calcium oxalate crystals

Fruit collection and extract preparation
Crystallization of CaOx
Crystallization without inhibitor
Crystallization with inhibitor
Microscopic observation
Crystal characterization
Discussion
Findings
Conclusion
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