Abstract
BackgroundThe amount of signal decreases when the acquisition duration is shortened. However, it is not clear how this affects the quantitative values. This study aims to clarify the effect of acquisition time shortening in brain tumor PET/CT using 11C-methionine on the quantitative values.MethodThis study was a retrospective analysis of 30 patients who underwent clinical 11C-methionine PET/CT examination. PET images were acquired in list mode for 10 min. PET images of acquisition duration from 1 to 10 min with 1-min step were reconstructed. We examined the effect on the quantitative values of acquisition duration. We placed a volume of interest to include the entire tumor and regions of interest in the shape of a large crescent in the contralateral hemisphere in 5 contiguous axial slices as normal tissue. Quantitative values examined were maximum, peak, and mean standardized uptake values (SUVmax, SUVpeak, SUVmean), metabolic tumor volume (MTV), and maximum tumor to normal tissue ratio (TNRmax), with each duration compared to that with 10 min.ResultsSUVmax, MTV, and TNRmax showed the highest values due to the effects of statistical noise when the acquisition time was 1 min. These values were stable when the acquisition duration was > 6 min. SUVpeak and SUVmean showed mostly consistent values regardless of duration.ConclusionsSUVmax, MTV, and TNRmax are affected by acquisition time. If the acquisition duration was > 6 min, the fluctuation could be suppressed within 5% in these quantitative values. However, SUVpeak was suggested to be a robust index regardless of the acquisition duration.
Highlights
If the acquisition duration was > 6 min, the fluctuation could be suppressed within 5% in these quantitative values
Positron emission tomography/computed tomography (PET/CT) with administration of 11C-methionine can be used for purposes such as discriminating between radiation necrosis and recurrence after radiation therapy, between tumor and non-tumor lesions, and for determination of the extent of brain tumor invasion. 11C-methionine PET/CT has been reported to be more useful than CT, magnetic resonance imaging (MRI), or 18F-fluoro-2-deoxy-D-glucose ([18F]FDG)-PET/CT [1,2,3]
Some clinical indexes such as standardized uptake value (SUV), maximum SUV within a region of interest (SUVmax) [4,5,6], peak SUV (SUVpeak) [7, 8], metabolic tumor volume (MTV) [9], and maximum tumor to normal tissue ratio (TNRmax) [10, 11] are widely used for diagnostic purposes in 11C-methionine PET/CT. To obtain these indexes with 11C-methionine PET/CT, an appropriate acquisition time has been reported to be 10 min, according to the standard protocol established by the Japanese Society of Nuclear Medicine (JSNM) [12]
Summary
Some clinical indexes such as standardized uptake value (SUV), maximum SUV within a region of interest (SUVmax) [4,5,6], peak SUV (SUVpeak) [7, 8], metabolic tumor volume (MTV) [9], and maximum tumor to normal tissue ratio (TNRmax) [10, 11] are widely used for diagnostic purposes in 11C-methionine PET/CT To obtain these indexes with 11C-methionine PET/CT, an appropriate acquisition time has been reported to be 10 min, according to the standard protocol established by the Japanese Society of Nuclear Medicine (JSNM) [12]. This study aims to clarify the effect of acquisition time shortening in brain tumor PET/CT using 11C-methionine on the quantitative values
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