Abstract
In our present study, the effect of alcoholic fraction of Pterospermum acerifolium seeds on inflammation and inflammatory cytokines was evaluated in-vitro by using human peripheral blood mononuclear cells (PBMCs) and in vivo by croton oil induced mouse ear edema (acute study) and Carrageen induced rat paw edema. The extract exhibited significant inhibition of the production of tumor necrotic factor- and interleukin-6 by PBMCs stimulated lipropolysaccirides (LPS) in a dose dependent manner. The extract, at the selected dose of 150 and 300mg/kg body weight per oral exhibited significant dose dependent anti-inflammatory response with 27.77% and 47.17% inhibition of inflammation in croton oil induced mouse ear edema and Carrageen induced rat paw edema respectively.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Pharmacognosy and Phytochemical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
