Abstract
Objective To study the effects of psychological intervention combined with dietary guidance on the quality of life and long-term efficacy of Bushen Quyu Decoction in the treatment of patients with advanced ovarian cancer. Methods 220 patients with advanced (stages III to IV) ovarian cancer in our hospital from May 2015 to October 2018 were selected and randomly divided into a control group and an observation group, with 110 cases in each group. The patients in the control group received basic nursing care and treatment with Bushen Quyu Decoction, and the patients in the observation group were combined with psychological intervention and dietary guidance on the basis of the treatment of the patients in the control group. The clinical efficacy, nursing satisfaction, treatment compliance, quality of life, negative emotion comparison, and long-term efficacy of the two groups were compared. Moreover, the changes of immune function indexes and the content of tumor markers were compared between the two groups. Results The total effective rate of treatment in the observation group (64.55%) was higher than that in the control group (31.82%). The nursing satisfaction of the observation group was 94.55%, the nursing satisfaction of the control group was 84.55%, and the difference was statistically significant (p < 0.01). The treatment compliance of the observation group was 98.18%, the treatment compliance of the control group was 82.73%, and the difference was statistically significant (p < 0.0001). After nursing, the Anxiety Self-Rating Scale (SAS) score and Self-Rating Depression Scale (SDS) score of the two groups of patients were decreased (∗p < 0.05), and the score of the observation group decreased more significantly (Δp < 0.05). After nursing, the scores of the two groups of patients in social/family status, physical function, physiological function, and emotional status increased (∗p < 0.05), and the observation group was significantly higher than the control group (Δp < 0.05). After nursing, the CD3+, CD4+, CD4+/CD8+ levels of the observation group were significantly higher than the control group (p < 0.05). The CD8+ level of the observation group was significantly lower than the control group (p < 0.05). After nursing, the levels of tumor markers in the two groups were decreased (∗p < 0.05), and the observation group was downregulated more significantly than the control group (Δp < 0.05). The two-year cumulative survival rate of the observation group was 78.18%, and the two-year cumulative survival rate of the control group was 54.55%. The observation group was significantly higher than the control group (p < 0.05). Conclusions Psychological intervention combined with dietary guidance can significantly improve the quality of life and mental state of patients with advanced ovarian cancer, enhance the patient's immune function, reduce the serum tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen (CA199) levels, and improve survival rate and survival time, which has important clinical significance.
Highlights
Ovarian cancer is one of the common gynecological malignancies in clinic with high morbidity and mortality [1]
Malnutrition in patients with ovarian cancer can lead to an increase in their mortality, which can be corrected by standardized nutritional therapy [9]. erefore, the continuous psychological intervention and the formulation of a reasonable diet plan for the patients can help improve the patients’ negative psychological mood, increase the patients’ confidence and courage to treat the disease, so as to improve the clinical efficacy, improve the patient’s quality of life, and prolong the patient’s survival time
220 patients with advanced ovarian cancer treated in our hospital from May 2015 to October 2018 were selected as the research objects, aiming to explore the effects of psychological intervention combined with dietary guidance on the quality of life and long-term efficacy of Bushen Quyu Prescription in the treatment of advanced ovarian cancer patients. e report is as follows
Summary
Ovarian cancer is one of the common gynecological malignancies in clinic with high morbidity and mortality [1]. The most effective way to treat advanced ovarian cancer is chemotherapy, which can inhibit the growth and spread of tumor cells through the pharmacological effects of chemotherapeutic drugs. By regulating the immune function of the body, it can improve the toxic and side effects caused by chemotherapy, inhibiting the metastasis and recurrence of cancer cells, improving the clinical efficacy, and prolonging the survival time [6, 7]. Erefore, the continuous psychological intervention and the formulation of a reasonable diet plan for the patients can help improve the patients’ negative psychological mood, increase the patients’ confidence and courage to treat the disease, so as to improve the clinical efficacy, improve the patient’s quality of life, and prolong the patient’s survival time. 220 patients with advanced ovarian cancer treated in our hospital from May 2015 to October 2018 were selected as the research objects, aiming to explore the effects of psychological intervention combined with dietary guidance on the quality of life and long-term efficacy of Bushen Quyu Prescription in the treatment of advanced ovarian cancer patients. e report is as follows
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