Abstract
Objective: Determine the effect of melatonin administration on sleep quality perimenopausal women based on PSQI and compare the results of PSQI before and after treatment.
 Methods: This study uses an experimental analytic study with Case Control design to determine the effect of melatonin administration on sleep quality perimenopausal women based on PSQI and compare the results of PSQI before and after treatment. This research was conducted at the Department of Obstetrics and Gynecology, H. Adam Malik General Hospital, Medan. The study population was all perimenopausal women who met the inclusion and exclusion criteria. This research was conducted from February to March 2020 with a sample of 25 people.
 Results: PSQI scores in the control group by age were 4.0±1.0 in the age group>50 y from 8.0±1.0; 2.17±1.62 in the group with tertiary education from 5.83±1.69; 2.56±1.67 in the non-working group of 6.44±1.51 and 2.31±1.6 in the multipara group of 6.0±1.58. From the analysis results obtained a value of P<0.001. This also showed a significant difference in the PSQI score in the control group. significant differences in PSQI values in the control group and melatonin group in the case group before getting melatonin (p<0.001), whereas after administering melatonin, no difference in PSQI score was found in the groups that received melatonin and the control group (p = 0.657)
 Conclusion: There are differences in PSQI scores in the case group before and after the administration of melatonin, in the control group who did not get melatonin and the difference in PSQI scores in the case group and the control group before treatment, but there were no differences in PSQI score in the case and control groups after treatment.
Highlights
Perimenopause is an obscure period time that surrounds the last years of a woman's reproductive life
We found there was no differences in case and control characteristics based on age, BMI, diastolic blood pressure, education and occupation (p = 0.769; p = 0.061; p = 0.210; p = 0.304; p = 1.00)
Based on table 2 we found that an increase in PSQI scores in the group before getting melatonin
Summary
Perimenopause is an obscure period time that surrounds the last years of a woman's reproductive life. These studies have allowed us to define the process of transition to menopause more fully and reveal specific changes in symptoms related to certain transition stages This long-term longitudinal cohort study includes a long follow-up period (9 and 20 y, respectively) and collects a lot of additional information about the quality of life, sexual function, bone density, and reproductive hormones. All of these studies are population-based or community-based, which are important considerations in efforts to define normal menopausal experiences for women. This is because most of our definitions of menopause are still based on menstruation [1, 2, 4]
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