Abstract
Pseudoephedrine (PSE) is a common sympathomimetic stimulant that is prohibited in large doses (> 150 µg·mL-1) by the World Anti-Doping Agency (WADA) yet unrestricted by the National Collegiate Athletic Association (NCAA). PURPOSE: To investigate the effect of body weight dosing of PSE on 800-m run times of NCAA female runners. METHODS: NCAA female track and field runners (N = 15) volunteered for a randomized, double-blind, crossover design. Runners were administered both a placebo and 2.5 mg·kg-1 PSE a week apart. Ninety minutes post-ingestion, participants completed an 800-m individual time trial on an indoor track. Finishing time was recorded with an automated video timing device. Placebo and PSE running times were compared using a paired t-test. RESULTS: Fourteen runners completed both trials and one was an outlier; N = 13. Despite being dosed (144 mg ± 17 mg) well above normal therapeutic levels, there was no significant difference (p = 0.92) in 800-m times between the placebo (2:39.372 ± 9.636) and PSE (2:39.447 ± 9.584) trials. CONCLUSION: A 2.5 mg·kg-1 dose of PSE had no effect on 800-m run times. This raises the question as to why PSE is a specified prohibited substance by WADA.
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