Abstract
ABSTRACT The present study was undertaken to evaluate the effects of several prostaglandins (PG) on the in vitro velocity of the reaction between human renin and homologous renin substrate. In the presence of high renin concentrations, 1.4 × 10−6 moles PGA1 and PGA2 each significantly inhibited the rate of angiotensin I production (p 0.05). At lower enzyme concentrations, PGA2 was a more potent inhibitor than PGA1. In the presence of physiologic renin concentrations, 1.4 × 10−9 moles PGA2 but not 1.4 × 10−10 moles PGA2 inhibited renin reactivity. Unrelated to differences of endogenous renin substrate concentration, renin reactivity in plasma of uremic patients was greater than that of normotensive control subjects, even after the addition of 1.4 × 10−9 moles PGA (p < 0.025). Renin inhibition was demonstrated by concentrations of PGA within the renal medulla, but not at the lower concentrations in peripheral venous plasma. Consequently, if PGA induced renin inhi...
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