Abstract
A number of investigators have found that intravenous injection of prostaglandin E1 (PGE1) or prostaglandin F2α(PGF2α) increased heart rate in humans (Bergstrom et al. (1)) and in dogs (Nakano and McCurdy (2); Emerson et al. (3)). Lavery et al. (4) also showed that the intra-vertebral arterial injection of PGE1 and PGF2α also increased heart rate in dogs. Nakano and McCurdy (2) showed that the tachycardia induced by intravenous injection of PGE1 was completely abolished by the administration of propranolol (1 mg/kg). The present study was undertaken to examine whether or not PGE1 or PGF2α has a direct effect on the sinus node by injecting the prostaglandins into an isolated sinus node artery.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
