Abstract
In the present study, we studied the effect of various prostaglandins (PGs) on alloxan-induced cytotoxicity to rat insulinoma (RIN) cells. Of all the PGs tested, PGE1, PGE2, PGI2, PGF1α, and PGF3α protected RIN cells from alloxan-induced cytotoxicity (P<0.05 compared to alloxan), whereas thromboxane B2 and 6-keto-PGF1α were not effective. PGE1 induces a statistically significant increase in the activities of superoxide dismutase and glutathione peroxidase and decrease in lipid peroxides in alloxan-treated RIN cells (P<0.001). PGE1 restored nitric oxide/lipid peroxide ratio to normalcy, suggesting that PGE1 suppresses oxidant stress induced by alloxan in RIN cells in vitro. Furthermore, PGE1 prevented DNA damage and apoptosis induced by alloxan. These results indicate that PGE1 prevents alloxan-induced cytotoxicity to RIN cells in vitro.
Published Version
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