Abstract
The effect of single intravenous and intramuscular injections as well as intra-amniotic and vaginal administration of PGE1 on the motility of the midpregnant human uterus was studied. Recording of uterine motility was made by measuring the amniotic pressure. Intravenous and intramuscular PGE1 stimulated the uterus predominantly by elevation of tone. The threshold dose of intravenous injection was found to be around 20 μg. One hundred micrograms caused a long-lasting sustained contracture. The influence of intravenous injection of PGE2 was compared with that of PGE1 and found to be approximately the same both qualitatively and quantitatively. Intra-amniotic or vaginal administration of PGE1 in high doses had no effect whatsoever on the pregnant uterus.
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