Effect of prostaglandin E1 lipid microsphere on cardiac haemodynamics and oxygen metabolism during the perioperative period in the infants with ventricular septal defect and severe pulmonary artery hypertension

Abstract

Objective To measure the effect of prostaglandin E1(PGE1) lipid microsphere on cardiac haemodynamics and oxygen metabolism during the perioperative period in the infants with ventricular septal defect(VSD)and severe pulmonary artery hypertension(PAH). Methods Forty infants[(7.1±3.3)years old] with VSD and severe PAH who underwent surgery under cardiopulmonary bypass were involved in the study.They were divided into 2 groups averagely: control group (20 cases) and experimental group (20 cases). All the patients were continuously intravenous pumping of nitroglycerin or PGE1 during the perioperative period.The effect of PGE1 on cardiac haemodynamics and oxygen metabolism between the 2 groups were measured during 72 hours postoperatively. Results The statistical analysis demonstrated that the values trend of mean arterial blood pressure (mABP), mean pulmonary arterial pressure(mPAP), mPAP/mABP, pulmonary vascular resistance index (PVRI), left ventricular stroke work index (LVSWI)were affected during 72 h postoperative period (P 0.05). Conclusions LipoPGE1 can significantly decrease the pulmonary arterial pressure, which can enhance cardiac function and decrease the duration of intubation after surgery. Key words: Congenital heart disease; Pulmonary arterial hypertension; Prostaglandin E1