Abstract
Sixteen patients with arteriosclerosis obliterans were treated intravenously with PGI2 at a dose of 5 ng/kg/min for a period of 72 hours. Three hours from the beginning of PGI2 infusion a non-significant decrease in platelet susceptibility to ADP, collagen and a suppression of TXA2 formation in collagen treated PRP were observed. However, continuation of the therapy was associated with an increased sensitivity of platelets to pro-aggregatory agents and an increased generation of TXA2 by PRP. Three hours from the beginning of the infusion of PGI2 thrombin time and recalcification plasma clotting time were significantly shortened while fibrinolytic activity as measured by euglobulin clot lysis time was doubled. Taking into account the above effects of PGI2 it is suggested that for treatment of thromboembolic disorders a period of three hours of PGI2 infusion or a shorter one would be more effective than 72 hours of PGI2 therapy.
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