Abstract
This study aimed to investigate the effects of ethyl acetate Prosopis farcta extracts on some complications associated with diabetes in rats. The experimental rats of 1.5-2 months old that weighed 190-220 g were randomly divided into six groups of seven animals each. Body weight, serum glucose, hematological changes and lipid profiles were studied. Alloxan was used of induction diabetes in rats. 252 rats were used anddifferent doses of the ethyl acetate extracts of roots, fruits, and leaves of P. farcta were orally administered daily for 28 daysfornormal and diabetic rats and the effective dose was 200 mg/kg BW for each kind of extracts. The results showed that administration of root, leaves and fruit extracts of P. farcta caused improvement in body weight, blood glucose, red blood cells (RBCs), hemoglobin (Hb), mean corpuscular hemoglobin (MCH), hematocrit (HCT orPCV) in alloxan diabetic rats in insulin like treatment manner, with the most effective improving effect for roots extract. Regarding to the effects on total and differential white blood cell (WBC) count, administration of extracts caused decrease in the total WBC and neutrophil count. Administration of root, leaves and fruit extracts of P. farcta, showed suppression in total cholesterol (TC), triglyceride (TG), very low-density lipoprotein (VLDL-C) and low-density lipoprotein (LDL-C), and increasing in high density lipoprotein (HDL-C) of alloxan diabetic rats. In conclusion, the P. farcta extracts possesses properties of improving some health complications accompanied diabetes in rats.
Highlights
Prosopis farcta extract was mentioned in the treatment of diabetes in traditional medicine [1]
Since diabetes is characterized by a rising of glycosylation of red blood cells (RBCs) membrane proteins, anemia is usually occurred by the destruction of these cells [14]
Reducing RBC, Hb, mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), HCT (PCV) and mean corpuscular volume (MCV) levels in the diabetic rats in this study may be due to the abnormalities on the normal body systems
Summary
Prosopis farcta extract was mentioned in the treatment of diabetes in traditional medicine [1]. The ethyl acetate extracts of P. farcta (roots, leaves, fruits) were orally administered daily for 28 days with different doses (50,100,150,200,250,300 mg/kg) in 1ml of physiological saline for each kind of extract. As the same way the effective dose was selected for parameters of body weight, hematology and lipid profiles and it was 200 mg/kg b.w for all extracts (roots, leaves, fruits) and all parameters [10]. The effective dose was 200 mg/kg for each kind of extract (roots, leaves and fruits) we considered it in our results, but other doses did not show significant changes. Effect of P. farcta extracts (roots, leaves and fruits) on the serum glucose in alloxan induced diabetic rats. The second one was leave extract the extract of fruits
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