Abstract
The effects of propylgallate (PrG) on the thermotropic behavior of dipalmitoylphosphatidylethanolamine (DPPE) and a phosphatidylcholine (PC)/PE mixture were studied by means of differential scanning calorimetry. The transition temperature ( T m ) of DPPE decreased and the transition peak became broad with an increase in the concentration of PrG. Subtransitions appeaerd by shorter time of storage at 2°C, compared with the case of DPPE only. A DPPC/DPPE (6:4) mixture gave one transition peak. PrG induced the formation of a DPPC-rich domain, causing phase separation. In a distearoylphosphatidylcholine/dilauroyl-phosphatidylethanolamine (DLPE) mixture, PrG also induced phase separation and had a stronger effect on DLPE. From these events, it was clear that the effect of PrG is stronger on the more fluid phospholipid in a PC/PE mixture. These effects of PrG on DPPE and a PC/PE mixture were quite different from those on DPPC or DPPG, which we previously reported (J. Biochem, 100, 1663–1668 (1986)., Chem.Phys. Lipids, 49, 225–230 (1989).). In this paper, we also discussed the interaction of PrG and each phospholipid.
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