Abstract
The aim of the study was to investigate the effect of propranolol upon protein synthesis and degradation processes in cell-free subfractions of rat myocardium in experimental cardiac hypertrophy induced by aortic stenosis. It was found that hypertrophy stimulates incorporation of 3H-amino acids by the postmitochondrial supernatant (PMS) by 17 +/- 4% (mean +/- SE). Propranolol 10 6M inhibited protein synthesis in the control and experimental groups by 37 +/- 5% and 34 +/- 7%, respectively. At a concentration of 5 X 10 6M, propranolol-induced inhibition in each group was 74 +/- 4% and 58 +/- 5%, respectively. The activity of neutral proteases in PMS of hypertrophic hearts increased up to 255 +/- 29 IU in comparison to 154 +/- 10 IU in controls; in the cytosol it was unchanged. Propranolol had no effect upon the activity of proteases in both fractions. Activity of calcium-activated neutral proteases (CANP) remained at the same level in control and hypertrophic hearts and was unaffected by propranolol.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
