Abstract
Severe burn injury is associated with increased peripheral lipolysis, which can be inhibited by administration of propranolol, a non‐selective beta‐adrenoreceptor antagonist. However, the mechanisms responsible for the effect of propranolol on the lipolytic response after severe burn injury are not known.Protein contents of adipose triglyceride lipase (ATGL), hormone‐sensitive lipase (HSL) and perilipin were assessed by western blotting in adipose tissue of 4 patients with severe burn injury and 4 patients with severe burn injury receiving propranolol. Subjects were matched for age (4±3 vs 4±6 years), % total body surface area burn (43±7 vs 49±10), and % 3rd degree burn (40±7 vs 45±6).Propranolol administration for up to 1 week decreased protein content of perilipin by 71% (P=0.06) and Ser‐563‐phosphorylated HSL (pHSL‐563) by 55% (P=0.05). Total HSL content decreased by 32% but did not reach statistical significance (P=0.08). ATGL and Ser‐660‐phosphorylated HSL (pHSL‐660) were not different in the two groups.These preliminary data suggest that propranolol administration acutely regulates specific molecules involved in adipose tissue lipolysis, providing a mechanism for the inhibitory effect of propranolol on adipose tissue lipolysis in severe burn injury.Sources of support: NIDRR (H133A070026 & H133A70019), NIH (P50‐GM60338, R01‐HD049471 & T32‐GM8256), and SHC (84080, 8741, 8660, 9145 & 8760).
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