Abstract
PURPOSEPropolis, which is a specific product of honeybee hive exhibits potential antioxidant and anti‐inflammatory properties. This study was designed to determine the effects of propolis on acid‐induced experimental colitis model in rats.METHODSThe experimental acid induced colitis was performed in 56 Wistar‐Albino rats according to Mann and Demers. Then rats were divided into two equal groups (Sl‐saline irrigation and Pl‐propolis irrigation). After preliminary saline irrigation in all rats either propolis (1.5 ml–100 mg/kg) or saline enema (1.5 ml) was administered by rectal route after acetic acid induction/In both groups irrigation procedure was performed in every 12 hours until colonic resection time. At 3rd – 7th – 10th and 14th post operative days rats were killed and distal colonic segments were harvested to determine the histopathological changes and tissue levels of malondialdehyde (MDA).RESULTSSeverity of the mucosal injury in Pl group was significantly lower when compared with the Sl group. Additionally MDA levels in Sl group was higher statistically significant than Pl group.COCLUSIONTopical administration of propolis as a rectal enema has significantly improved rectal mucosal restoration rate and both histopathological parameters and MDA levels on acid‐induced colitis model.
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