Abstract
This study evaluates clinically the effect of propolis paste on healing of cutaneous wound in dogs. Under general anesthesia and complete aseptic conditions, two full thickness skin wounds (3 cm diameter) were created in each side of the chest in five dogs, one dorsal and one ventral, with 10 cm between them. These wounds were randomly allocated into two groups, control group (10 wounds) and propolis group (10 wounds). Both groups were represented in each dog. The wounds were cleaned with normal saline solution and dressed with macrogol ointment in control group and propolis paste in propolis group, twice daily till complete wound healing. Measurement of the wound area (cm2) was monitored planimetrically at 0, 7, 14, 21, 28, and 35 days after injury. The data were analyzed statistically. The results revealed a significant reduction in the wound surface area in the propolis group after 14 and 21 days compared to control group. The wound reepithelization, contraction, and total wound healing were faster in propolis group than in control group during five weeks of study. In conclusion, propolis paste has a positive impact on cutaneous wound healing and it may be suggested for treating various types of wounds in animals.
Highlights
Wound healing results from a complex tissue repairing process to replace devitalized and missing cellular structures and tissue layers
Several wound healing agents are used in veterinary practice, new agents are usually discovered [1]
Propolis is a resinous material collected by bees from plants exudates and buds and mixed with wax and bee enzymes
Summary
Wound healing results from a complex tissue repairing process to replace devitalized and missing cellular structures and tissue layers This process is divided into four precisely and highly programmed phases including blood clotting, inflammation, the growth of new tissue (proliferation), and the remodeling of tissue (maturation). Propolis is a resinous material collected by bees from plants exudates and buds and mixed with wax and bee enzymes. It consisted of 30% beeswax, 50% resins and vegetable balsams, 10% essential oils, 5% pollen, and 5% other substances. Geopropolis is produced by indigenous stingless bees and it is composed of resinous material of plants and soil or clay [3]
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