Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection.

Jelena Vekić,Milica Miljković,Jelena Janać,Nataša Bogavac-Stanojević,Jelena Kotur-Stevuljević,Marija Mihajlović,Jasmina Ivanišević,Vesna Spasojević-Kalimanovska,Dejan Zujović,Sanja Vujčić,Aleksandra Zeljković

doi:10.5937/jomb0-24695

Jelena Vekić, Milica Miljković + Show 9 more

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https://doi.org/10.5937/jomb0-24695

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Journal: Jugoslovenska medicinska biohemija	Publication Date: Jan 1, 2020
Citations: 6	License type: CC BY 4.0

Abstract

Propolis and N-acetylcysteine have positive impact on respiratory tract health. Also, it has been suggested that they have beneficial effects on serum lipid and oxidative stress status, but the available data are limited and mostly gained from animal models. In this study we evaluated the effects of propolis and N-acetylcysteine supplementation (PropoMucil®) on lipid status, lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection. Twenty subjects with acute respiratory infection were included. PropoMucil® granules for oral solution (80 mg of dry propolis extract and 200 mg of N-acetylcysteine) were administered tree times per day for ten days. Serum lipid profile, paraoxonase 1 activity and low-density and high-density lipoprotein size and subclasses distribution were assessed at baseline and after supplementation. Following ten days of supplementation lipid status remained unchanged, but a significant increase of low-density lipoprotein particle size and proportion of high-density lipoprotein 3a particles were found (P<0.05). Moreover, supplementation with PropoMucil® significantly improved high-density lipoprotein particles distribution, particularly in those who smoke. There was a moderate increase of paraoxonase 1 activity, but without statistical significance. The presented study demonstrated that short-term supplementation with PropoMucil® has beneficial effects on low-density and high-density lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection particularly in those who smoke.

Highlights

Acute respiratory infections (ARI) are the most common infective diseases of respiratory tract and most frequently have viral aetiology [1]
Serum lipid profile in acute phase response is characterised by elevated triglycerides (TG) and reduced high-density lipoprotein cholesterol (HDL-C) levels, while the concentration of total (TC) and lowdensity lipoprotein cholesterol (LDL-C) might be normal or slightly elevated
Lowgrade inflammation leads to profound disorders of lipoprotein metabolism and dyslipidemia [5] and ARI and smoking may be associated with chronic pulmonary disease or chronic inflammatory state, disturbances in lipoprotein metabolism are more expected to occur

Summary

Introduction

Acute respiratory infections (ARI) are the most common infective diseases of respiratory tract and most frequently have viral aetiology [1]. Lowgrade inflammation leads to profound disorders of lipoprotein metabolism and dyslipidemia [5] and ARI and smoking may be associated with chronic pulmonary disease or chronic inflammatory state, disturbances in lipoprotein metabolism are more expected to occur. Lipid peroxidation of LDL particles is the common link between oxidative stress and dyslipidemia and the initial step in atherogenesis [6]. Another important link is paraoxonase 1 (PON1), an enzyme associated with HDL particles, which protects LDL against lipid peroxidation [7]

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