Abstract
The effect of hyperprolactinemia on bile excretion from the liver of female rats was shown to increase significantly during obstructive cholestasis. The observed changes were biphasic: initial increase in bilirubin release of into the bile was followed by its reduction. Under conditions of obstructive cholestasis, hyperprolactinemia had a negative effect on the recovery of bile flow rate during decompression of the duct (up to complete cessation of bile flow).
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