Abstract
The influence of progesterone upon 5-hydroxytryptamine (5-HT) metabolism in the rat brain was investigated in view of a possible connection with premenstrual tension and postpartum depression. A progesterone dose, resulting in a plasma level which was still in a physiological range, increased 5-HT turnover in septum, hypothalamus and raphe. A higher unphysiological dose, besides producing a further increase of 5-HT turnover, also resulted in a decrease of 5-hydroxyindoleacetic acid (5-HIAA) levels which was most pronounced in the septum. Neither of the two doses showed a clearcut influence on 5-HT concentrations in any of the investigated brain areas.
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