Abstract
IntroductionRecent research from both human and animal studies confirms that cognitive training gains a considerable effect on multiple cognitive domains in older adults with mild cognitive impairment. Previous studies have yet paid scant attention to executive function training. Little is known about whether this specific benefit translates to maintaining long-term effectiveness and transfer effects are. This study is designed as an effort to address this issue.ObjectiveThe program aimed to evaluate the effect of process-based multi-task cognitive training on executive function and further explore its long-term effects and transfer effects in older adults with MCI. Furthermore, we will explore the neural correlates latent the changed performances underlying the cognitive intervention.MethodsThis program is a single-blinded, randomized, prospective clinical trial to test the effect of process-based multi-task cognitive training in older adults with MCI. Ninety participants with MCI will be recruited and randomly assigned to the cognitive training group (n=45) and the wait-list control group (n=45). The cognitive training group will receive 10 weeks of process-based multi-task cognitive training and health education twice a week, at 40~60 min per session. While the wait-list control group will only receive 10 weeks of health education during the research period. The effect is measured using the executive function, neuropsychological assessment performance and related brain activity assessed with electroencephalogram parameters (slowness and complexity of the EEG) at baseline, after 10 weeks of training, and a 3-month follow-up.ResultsThe study is currently ongoing. Recruitment began in March 2019 and will conclude at the end of 2020. Effects of the process-based multi-task cognitive training on executive function in older adults with MCI will be described in intention-to-treat analysis and protocol set principle. We will also explore the potential long-term effects and transfer effects.DiscussionIf a process-based multi-task cognitive training program results in positive changes to executive function in older adults with MCI, this might provide a viable and potential approach to delay the cognitive decline. Clinical Trial Registration: ChiCTR1900020585. Registered on January 09, 2019. http://www.chictr.org.cn/showproj.aspx?proj=34664.
Highlights
Recent research from both human and animal studies confirms that cognitive training gains a considerable effect on multiple cognitive domains in older adults with mild cognitive impairment
Given that the limitations of cognitive training for older adults with Mild cognitive impairment (MCI) reported by previous researches, we developed a process-based multi-tasks cognitive training program based on the process model [29, 30], which was targeted to improve the executive function of older adults with MCI
The primary aim of this study is to evaluate whether the process-based multi-task cognitive training program would provide better results on executive function in older adults with MCI
Summary
Recent research from both human and animal studies confirms that cognitive training gains a considerable effect on multiple cognitive domains in older adults with mild cognitive impairment. Previous studies have yet paid scant attention to executive function training. Mild cognitive impairment (MCI) represents an intermediate state between normal or healthy ageing and early-stage dementia [1]. The reversion from MCI to NC maybe benefit from appropriate cognition management/intervention [8]. Memory impairment is a major manifestation of MCI, preclinical deficits in executive function are widely observed in older adults with MCI [9, 10]. The executive function is a crucial predictive factor in dementia prognosis [11]. Older adults with MCI with lower executive function demonstrated more
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