Abstract
Objective To investigate the effect of Probucol combined with Enalapril-folic acid tablets on endothelial function in elderly patients with H-type hypertension. Methods A total of 180 elderly patients with H-type hypertension were randomly divided into three groups (n=60, each): Group A (conventional treatment), Group B (conventional treatment + a tablet containing 10 mg enalapril and 0.8 mg Folic acid/day) and Group C (conventional treatment + 500 mg Protocol twice daily + a tablet containing 10 mg Enalapril and 0.8 mg folic acid/day). Plasma hemocyanin (Hcy) and asymmetric dimethylarginine (ADMA) levels and serum nitric oxide (NO) and endothelial NO synthase (eNOS) levels were measured before treatment, and 1 and 6 months after treatment. Results In Group A, plasma Hcy and ADMA levels and serum NO and eNOS levels had no significant differences before treatment versus 1 and 6 months after treatment (P>0.05). Plasma Hcy and ADMA levels decreased and serum NO and eNOS levels increased in Group B 6 months after treatment, compared with those at pretreatment or 1 month after treatment, which were either lower or higher than those in Group A 6 months after treatment (all P<0.05). Plasma Hcy and ADMA levels decreased and serum NO and eNOS levels increased in Group C 6 months after treatment, compared with those at pretreatment or 1 month after treatment, which were either lower or higher than those in Groups A and B 6 months after treatment (all P<0.05). After adjustment for other risk factors, partial correlation analysis showed that plasma ADMA was positively correlated with plasma Hcy, while plasma ADMA and Hcy were negatively correlated with serum eNOS and NO (all P<0.05). Conclusions Probucol in combination with Enalapril-folic acid tablets may be beneficial in improving endothelial function and mitigating the development of atherosclerosis. Key words: Hypertension; Endothelium, vascular
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