Abstract
The aim of our study was to investigate the dependence of carbohydrate metabolism in patients with arterial hypertension and concomitant abdominal obesity depending on Pro197Leu polymorphism of the GPX1 gene. Pro197Leu polymorphism of the gene GPX1 in 102 patients with arterial hypertension and concomitant abdominal obesity and 97 healthy individuals have been studied. Disorders of distribution of genotype frequencies comparing with the control group on account of the reduction of Pro/Pro genotype frequency have been found in the main group. Analyzing the data, the growth of risk of disorder in the GPX1 activity in patients with Pro/Leu and Leu/Leu variants of polymorphism comparing with homozygotes for the wild allele at 4.7 and 6.9 times, respectively had been revealed. Analyzing changes of carbohydrate metabolism depending on the Pro197Leu polymorphism of the gene GPX1, it was established that in patients with Leu/Leu genotype the production of immunoreactive insulin, leptin, C-peptide increased significantly, HOMA-IR and BMI was significantly higher compared with the persons with Pro/Pro genotype. Thus, Pro-allele possesses protective properties as to the reduction in the activity of glutathione peroxidase. Insulin and leptin resistance develop in the carriers of Leu-allele, which causes disturbances in carbohydrate metabolism.
Highlights
Cytoplasmic glutathione peroxidase (GPX1) is one of the selenoenzymes important for the organism functioning, present in all tissues of the human body, which takes part in detoxication of hydrogen peroxide and products of lipid peroxidation, as catalyzes the interaction of reduced glutathione with these substances [4, 6, 8, 10]
We studied single nucleotide polymorphism of the gene GPX1 for going into the question of the dependence of these processes upon the disorders of redox homeostasis
The aim of the study: to investigate the dependence of carbohydrate metabolism in patients with arterial hypertension and concomitant abdominal obesity depending on Pro197Leu polymorphism of the GPX1 gene
Summary
Cytoplasmic glutathione peroxidase (GPX1) is one of the selenoenzymes important for the organism functioning, present in all tissues of the human body, which takes part in detoxication of hydrogen peroxide and products of lipid peroxidation, as catalyzes the interaction of reduced glutathione with these substances [4, 6, 8, 10]. We studied single nucleotide polymorphism of the gene GPX1 for going into the question of the dependence of these processes upon the disorders of redox homeostasis. Several single nucleotide polymorphism variants of this gene have been known, but the Pro197Leu polymorphism has been under our study, at which in the position 593 the amino acid cysteine (C) is replaced with thymine (T) (C593T), resulting in substitution of the amino acid proline for leucine in the 197 codon. This mutation refers to missense — functional polymorphisms [1]. The presence of Leuallele causes depression of GPX1 sensibility to stimulating factors [5]
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