Abstract
ConclusionsAndrogen sterilization results in the elimination of the multiphasic dose-response curve obtained with the OCD bio-assay for LH. The dose-response curve in the androgenized animals is highly reproducible, but the sensitivity of the assay is considerably reduced. The abolition of the multiphasic curve by androgen treatment suggests that endogenous LH release is responsible for the multiphasic type of response in the non-androgenized rat. A linear log dose-response relationship for LH is obtained between 0.0625 μg and 0.25 μg using a 5-hour assay time interval, and between 0.25 μg and 1.0 μg using a 7-hour assay time interval. This response is reproducible and is specific for LH.
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