Abstract
Objective: The aim of this study was to evaluate the effects of rectal midazolam premedication on hemodynamic parameters and BIS values in children undergoing general anesthesia (GA) for dental rehabilitation. Study Design: Records of 30 children aged 2 to 7 years were retrieved and divided into 2 groups. Group 1 received midazolam 0.3mg/kg body weight rectally, and group 2 involved children who did not receive any presedative (control). Mean arterial blood pressure (MAP), heart rate (HR), oxygen saturation (SpO 2 ), and BIS were evaluated (1) before laryngoscopy; (2) 1 min; (3) 5 min; (4) 10 min after nasotracheal intubation; (5) at the time of extubation; and (6) at the time of recovery. Paired t-test was performed to analyze all data. p 0.05), but increased significantly in control group 1 min after intubation (p 0.05). The BIS records of the midazolam group were slightly lower than the control group in general, but this difference was insignificant (p>0.05). Conclusion: Midazolam premedication prior to GA induction resulted with lower MAP and HR than the control group immediately after intubation whereas it did not alter BIS values remarkably at all time intervals.
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