Abstract
OBJECTIVESThe global prevalence of preterm labor is approximately 11.1% of live births. However, preterm labor contributes to 75-80% of neonatal morbidity and mortality. The morbidity experienced by preterm infants may continue to influence their subsequent development, imposing physical, psychological, and economic burdens. Premature rupture of membranes (PROM) is a causal factor that may affect preterm birth. Previous studies have shown an association between PROM and preterm labor, but this association should be investigated in more diverse populations. Therefore, this study was conducted in Cilegon, Indonesia to determine the magnitude of the risk of preterm labor associated with PROM at Cilegon Hospital from July 2014 to December 2015.METHODSThis case-control study used data from patients’ medical records. The cases were all mothers who delivered at less than 37 weeks of gestation, while the control population comprised all mothers who delivered at greater or equal to 37 weeks. The data were analyzed using logistic regression.RESULTSThe bivariate analysis yielded an odds ratio (OR) of 2.97 (95% confidence interval [CI], 1.92 to 4.59) before controlling for covariates. The model derived through multiple regression analysis after controlling for education, history of preterm labor, and anemia resulted in an OR of 2.58 (95% CI, 1.68 to 3.98).CONCLUSIONSMothers who experience PROM during pregnancy were at a 2.58 times higher risk of preterm labor after controlling for education, history of preterm labor, and anemia.
Highlights
The reduction in neonatal mortality targeted as part of the Millennium Development Goals has not yet been fully achieved
Apart from Premature rupture of membranes (PROM), other variables studied included maternal characteristics, previous obstetric history, and variables related to the current pregnancy
Women with a PROM latency period (LP) of > 12 hours had a preterm labor risk of 3.55 compared with women who did not have PROM. These results indicated a dose-dependent relationship, in that a longer LP increased the risk of preterm labor
Summary
The reduction in neonatal mortality targeted as part of the Millennium Development Goals has not yet been fully achieved. An important barrier to progress toward achieving this goal is death. Preterm childbirth refers to the delivery or birth of a baby with a gestational age of less than 37 weeks, in which gestational age is calculated based on the mother’s last menstrual period [2]. Preterm labor accounts for as much as 75-80% of neonatal morbidity and mortality [3]. Preterm infant morbidity imposes physical, psychological, and economic burdens on babies, mothers, and families. Approximately 11.1% of live births are preterm deliveries [1,2,4,5,6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
