Abstract
To investigate the effect of pre-injection Shenfu injection on the hemodynamics of radical resection of colorectal cancer in elderly patients with hypertension. The candidates were randomly divided into control group (receiving pre-injection of sodium chloride injection) and research group (receiveing pre-injection of Shenfu injection) before anesthesia induction. The perioperative hemodynamic changes and use of vasoactive drugs were compared. Mean arterial pressure (MAP), diastolic blood pressure (DBP) and systolic blood pressure (SBP) values in the research group were lower than those in the control group at the time of tracheal tube extraction (P < 0.05). The use rate of antihypertensive drugs in the research group was lower than those in the control group (P < 0.05). Pre-injection of Shenfu in elderly hypertensive patients had no influence on anesthesia effect and it can reduce the volatility of hemodynamic parameters, decrease the use of vasoactive drugs.
Highlights
In recent years, the incidence of colorectal cancer has gradually increased (Balthazar et al, 2021; Gaspar-Pintiliescu et al, 2020; Rafiq et al, 2020)
Once cardiac excessive or hypertension reaction appeared in the process of anesthesia induction or operation, it will cause the increase of blood pressure and myocardial oxygen consumption, even many serious complications, such as cerebral infarction, heart failure, especially in elderly patients with hypertension (Hart, 2018; Lang et al, 2017)
This study showed that though pre-injection of Shenfu injection had no significant effect on Mean arterial pressure (MAP), diastolic blood pressure (DBP) and systolic blood pressure (SBP) values at the time of admission, the SBP before tracheal intubation in patients pre-injection with Shenfu injection was higher than that in patients pre-injection of 0.9% sodium chloride, which may be related to the effect of raising blood pressure at one time for aconitine alkaloids in Shenfu injection
Summary
The incidence of colorectal cancer has gradually increased (Balthazar et al, 2021; Gaspar-Pintiliescu et al, 2020; Rafiq et al, 2020). Once cardiac excessive or hypertension reaction appeared in the process of anesthesia induction or operation, it will cause the increase of blood pressure and myocardial oxygen consumption, even many serious complications, such as cerebral infarction, heart failure, especially in elderly patients with hypertension (Hart, 2018; Lang et al, 2017). Life safety and prognosis in elderly patients are directly related to perioperative hemodynamic stability. In order to maintain the stability of vital signs of elderly patients during perioperative period and ensure the safety of elderly patients, it is necessary to minimize the incidence of adverse stress response to reduce the physiological and psychological stimulation of the body (Sun et al, 2018). Patients with hypertension and colorectal cancer were pre-injected with Shenfu injection before laparoscopic radical operation to investigate the effect of Shenfu injection on the hemodynamics in elderly patients
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