Abstract
Background The aim of this study was to compare the anti-inflammatory effects of dexamethasone and etoricoxib after third molar extraction. Material and Methods A prospective, randomized, controlled, split-mouth study was conducted. 19 volunteers were allocated randomly to receive 90mg etoricoxib 1 hour prior to the procedure or 4mg intramuscular dexamethasone immediately after anesthesia. Baseline measurements were obtained preoperatively, and subsequent assessments were made on immediate postoperative, at 72 hours and 7 days after surgery to measure postoperative facial swelling by use of linear measurements, interincisal mouth opening width and visual analog scale score for pain. The amount of analgesics consumed was recorded. Descriptive statistics and the independent-samples t-test were used to compare the two groups at P < 0.05. Results Dexamethasone was effective in the control roasted edema for measurements of the mandibular angle - wing of the nose and mandibular angle - labial commissure 72 hours after surgery. And for the measurement mandibular angle - mentum, in the time of 72 hours and 7 days. There was no statistically significant difference in relation to pain and trismus. Conclusions Considering significant results for some measures of the variable edema for the group that used intramuscular dexamethasone and the difference without statistical significance between groups for the other variables studied, we seem to reflect the intramuscular indication of the corticosteroid in a single dosage in relation to the use of etoricoxib as pre-emptive medication. Key words:Corticosteroids, COX-2 selective, third-molar surgery.
Highlights
The extraction of mandibular third molars is the most frequent intervention in oral surgery [1,2]
Excessive swelling, pain and trismus are often associated with this type of surgery, [3,11,12] the intensity of which varies with the extent of the trauma, which is directly related to the degree of surgical difficulty
The present study evaluated the effectiveness of an NSAID administered orally and a corticosteroid administered intramuscularly, which are widely used classes of drugs in third molar extractions [4,14]
Summary
The extraction of mandibular third molars is the most frequent intervention in oral surgery [1,2]. The injection of corticosteroids in the medial pterygoid muscle is acceptable, since this is an area that is anesthetized during the operation and this method eliminates the possibility of gastrointestinal side effects [7] Another method for preemptive analgesia is the use of NSAIDs, which reduce the synthesis of prostaglandins derived from arachidonic acid through the inhibition of the enzyme cyclooxygenase (COX). The aim of the present study was to compare the anti-inflammatory effects of dexamethasone administered to the medial pterygoid muscle and etoricoxib administered orally following third molar extractions. Conclusions: Considering significant results for some measures of the variable edema for the group that used intramuscular dexamethasone and the difference without statistical significance between groups for the other variables studied, we seem to reflect the intramuscular indication of the corticosteroid in a single dosage in relation to the use of etoricoxib as pre-emptive medication
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