Abstract
BackgroundPreemptive analgesia has as its basic principle the administration of analgesics before the onset of painful stimuli, in order to reduce or prevent postoperative pain, but this question is little explored in implantology. Thus, this study was conducted in order to evaluate the clinical efficacy of ibuprofen in pain prevention after unit implant surgery. Material and MethodsFor this triple-blind, parallel, placebo-controlled and randomized clinical trial, 54 insertion surgeries of unitary implants were performed. Two groups have received two different protocols 1 hour before surgery: Ibuprofen group (IBU) 600 mg of ibuprofen; and (2) placebo group (maize starch). The intensity of the pain was evaluated through the visual analogue scale (VAS) in 6 times (1, 6, 12, 24, 48 and 72 hours after the surgery). Patients were instructed to take 750 mg of paracetamol as rescue medication, if necessary. The occurrence and the intensity of pain were analyzed by means of an analysis of variance ANOVA with repeated measurements using the general linear model procedure. ResultsThe IBU group had significantly lower VAS scores overall (IBU = 0.30, ± 0.57; placebo = 1.14, ± 1.07; p<0.001) and at all times in the intra, intergroup comparisons and time/group interaction than the placebo group (p<0.001). The use of rescue medication was significantly lower and the postoperative time was longer in the IBU group compared to placebo (p = 0.002). ConclusionsThe single use of ibuprofen was found to be significantly superior in reducing pain after unit implant surgery compared to placebo. Key words:Analgesia, dental implants, pain, surgery, oral.
Highlights
Pain is a factor hardly dissociated from dental treatment [1]
Analyzing the plurality of factors that may interfere with perceived pain [4], the absence of differences in almost all variables surveyed between the groups in our study seems to contribute to the validation of our findings
There is a tendency in preemptive analgesia (PA) to test steroid and non-steroidal anti-inflammatory drugs with only one study testing the use of ibuprofen
Summary
Pain is a factor hardly dissociated from dental treatment [1]. Their presence or only the possibility of feeling it can trigger innumerable reactions such as fear and anxiety, which can directly interfere with the safety of looking for a particular treatment [2,3,4]. Studies have shown a high preference for the use of Ibuprofen in pain control related to dental problems or dental procedures [12,16,19] Ibuprofen, a name derived from the initials of isobutylphenyl propionic acid, is a drug in the group of NSAIDs which acts by non-selectively inhibiting cyclooxygenase 1 and 2 avoiding the consequent formation of pro-inflammatory mediators by the arachidonic acid cascade [19] In this sense, the hypothesis for this study was that individuals who receive PA with the use of ibuprofen (600 mg, oral) 1 hour before the implant surgery present lower postoperative pain in relation to individuals receiving placebo medication. Conclusions: The single use of ibuprofen was found to be significantly superior in reducing pain after unit implant surgery compared to placebo
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