Effect of prednisone on secretion of enzymes in the alimentary tract

Abstract

The effect produced by prendisone on the secretion of digestive juices and enzymes was studied. Experiments were staged on dogs, in which isolated stomach pouches and fistulae of the pancreas were formed after Pavlov, and intestinal segments were isolated. Prednisone was given once a day/os (0.3 mg/kg of body weight). The hormone was administered for 4 weeks according to the hormone therapy scheme accepted at the clinic. During the administration of the preparation there was a rise of pepsin concentration in the gastric juice, of amylase and lipase — in the pancreatic juice, and of enterokinase — in the intestinal juice. The secretion of digestive juices decreased, as a rule, by the end of the 3rd–4th week.