Abstract
Praziquantel (PZQ) has been used for treatment of fish parasites for a long time. However, limited investigations exist implying its immunomodulatory properties in fish species. In the present study, the effects of bath administration of therapeutic doses of PZQ on immune responses of common carp, Cyprinus carpio, were investigated. Fingerlings of C. carpio were given 24-h bath immersion in 0.5, 1.5 and 5 mg/l PZQ solutions, and the immune responses were assessed on 1, 7, 14, 21 and 28 days post-PZQ administration in comparison with the controls. Data revealed that the medium and high doses (1.5 and 5 mg/l, respectively) significantly (p < 0.05) enhanced some specific and non-specific immune parameters namely specific antibody titer, serum lysozyme and bactericidal activities, phagocytic and respiratory burst activities, disease resistance, total plasma protein and immunoglobulin level. This study provides preliminary evidence for immunomodulatory properties of PZQ in fish and its potential capacity as an immunostimulant in common carp.
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