Effect of PRAC combined with laparoscopic surgery on the expression of serum GROβ and ANGPTL2 in patients with colorectal cancer

Abstract

Objective To investigate the expression of growth related oncogene protein serum beta (GROβ) and angiopoietin like protein 2 (ANGPTL2) in the stageⅡ,Ⅲ colorectal cancer (CRC) patients with preoperative regional arterial perfusion chemotherapy (PRAC) combined with laparoscopic surgery. Methods From January 2015 to January 2017, one hundred CRC patients of stageⅡ,Ⅲ in Pidu District People's Hospital of Chengdu City were selected. According to the random number table, they were divided into laparoscopic group (laparoscopic surgery) and combined group (PRAC combined with laparoscopic surgery), with 50 cases in each group. In addition, 50 CRC patients of stageⅡ and Ⅲ CRC treated by laparotomy were selected as the control group. The short-term curative effect, the levels of serum GROβ and ANGPTL2 protein and incidence of postoperative complications were compared among the three groups. Results (1) The length of incision, amount of bleeding and length of stay in laparoscopic group and combined group were lower than those in the control group (t=275.46, 3.47, 56.15, all P<0.05). (2) The overall complication rate in laparoscopic group and combined group was lower than the control group (14.0%, 12.0%, 30.0%, χ2=6.41, P=0.04), while there was no significant difference between the laparoscopic group and combined group (χ2=0.09, P=0.77). (3) Compared to pre-treatment, the levels of serum GROβ were increased, and the levels of ANGPTL2 were decreased in the three groups (P<0.05). The levels of serum GROβ and ANGPTL2 in combined group were lower than the laparoscopic group and control group. Similarly, the above indicators in laparoscopic group were lower than those in control group (P<0.05). (4) Postoperative metastasis and recurrence rate were 6.0% and 4.0% in combined group, which were lower than the laparoscopic group of 22.0%, 24.0% and control group of 28.0% and 28.0%, the differences were statistically significant (χ2=8.52, 10.89, P=0.014, 0.004); but no statistical difference was found between the laparoscopic group and control group. Conclusion The short-term curative effect of PRAC combined with laparoscopic surgery for colorectal cancer is better than that of single laparoscopic surgery, and can decrease serum GROβ and ANGPTL2 levels. Key words: Colorectal neoplasms; Chemotherapy, cancer, regional perfusion; Laparoscopes; GROβ; ANGPTL2