Effect of PP2A concentration on the carcinogenicity of MCs

Abstract

Microcystins (MCs) are normal FHAB toxins that are harmful to humans. The toxicological mechanism of MCs is to form covalent bonds with serine protein phosphatases and disrupt the phosphorylation process of cells. Which leads to hyperphosphorylation, which leads to tumor formation. This study tries to study whether keep the process of phosphorylation of cells by increasing the PP2A concentration. Method The experiment will use the animal model, Western blot test for Akt activation, Thr308 and Ser473 within Akt, and PP2A activated acid test.