Effect of potentiated anesthesia of dexmedetomidine in patients with incomplete brachial plexus block

Abstract

Objective To evaluate the effect of potentiated anesthesia of dexmedetomidine (DEX) when brachial plexus block were unsuccessful.Methods 42 patients with incomplete brachial plexus block were randomly divided into 2 groups(group A and group B,n=21).Sauteralgyl 25 mg and droperidol 2.5 mg were used in group A,0.8 μg/kg of DEX were used in group B within 10 min as a bolus,and 0.4 μg ·kg-1 ·h-1 of DEX were infused continuously until the end of the operation.Systolic blood pressure (SBP),diastolic blood pressure (DBP),heart rate (HR),transcutaneous oxygen saturation (SpO2),visual analogue scale (VAS),Ramsay score and other side effects were recorded before potentiated anesthesia (T0) and 5(T1),10(T2),30 min (T3) after potentiated anesthesia and end of operation(T4).Results Compared with group A,VAS were lower in group B[0(3.5) vs 3.5(3),0(1)vs 2(2.75),0(1) vs 2.5(3) at T1,T2,T4,respectively,P＜0.05].The Ramsay score in group B were higher than that of group A [(2.8±0.9) vs (1.8±0.9),(3.9±0.3) vs (2.8±0.9),(3.7±0.7) vs (2.7±0.9),(2.3±0.6) vs (1.3±0.8) at T1,T2,T3,T4,respectively,P＜0.01].There were no significant difference between two groups in other side effects such as hypotension,sinus bradycardia,nausea and vomiting(P＞0.05).There were no significant difference between two groups at each time point in SBP,DBP,HR and SpO2(P＞ 0.05),although there were significant difference among each group in SBP,DBP,HR(P＜0.01).Conclusions DEX can be used to strengthen the effect of brachial plexus block,with good analgesia and sedation,and high safety. Key words: Dexmedetomidine; Potentiated anesthesia; Brachial plexus; Nerve block