Abstract
In a series of investigations on the compensatory hypertrophy of the thyroid gland in guinea pigs, it was found that within the normal gland there was discernible a formation of three layers which differed in (1) the size of acini, (2) the more or less solid state of the colloid, (3) the quantity of this substance and (4) the height or flatness of the epithelium lining the acini. There is usually associated with a greater hardness and a greater quantity of the colloid a greater flatness of the epithelium.1 This suggested that the character of the epithelium lining the acini may be determined, at least in part, by the condition of the colloid, and in particular by the presence or absence of pressure exerted upon the epithelium by this substance, and by surrounding acini. There was some apparent confirmation of this view in the further observation that, not rarely, the walls separating neighboring acini may be broken through, and that such a change may be followed by the union of the colloid material of bot...
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