Effect of postoperative different drinking water methods on prevention of contrast-related renal injury after CT angiography

Abstract

Objective To explore the effect of postoperative different drinking water methods on prevention of contrast-induced nephropathy(CIN) after CT angiography. Methods A total of 84 patients who underwent CT angiography were enrolled from October 2015 to October 2016. All patients were randomly divided into observation group (n=42) and control group (n=42) .The patients in control group were applied with routine drinking water, volume of water≥2000 mL within 24 hours , but no requirement for the amount of water per unit time happened. The patients in observation group were applied with short-term potable water, and drinking 400~500 mL per hour at 1, 2, 3 hours after surgery, and 24 h drinking water≥ 2000 mL. Incidence of CIN and secondary end point events, serum creatinine (Scr), blood urea nitrogen (BUN), glomerular filtration rate (GFR), and β-microglobulin were measured and compared before and 24 hours after operation between the two groups. Results The incidence of CIN and secondary end point events in the observation group were lower than those in the control group (P<0.05). The levels of Scr, BUN and β-microglobulin in the observation group were lower than those in the control group at 24 h (P<0.05), while the GFR was higher in the observation group than that in the control group (P<0.05). Conclusions Short-term intensive drinking water can effectively reduce the incidence of CIN and secondary end point after CT angiography, and can help to reduce the damage of renal function by contrast agent. Key words: Kidney; Tomography, X-Ray Computed