Abstract
Coffee is believed to prevent postoperative ileus. This systematic review and meta-analysis was undertaken to determine the effectiveness of coffee consumption in stimulating gastrointestinal function after abdominal surgery. A number of databases for randomized controlled trials comparing coffee consumption following abdominal surgery versus water drinking or no intervention were searched. Cochrane’s Risk of Bias tool was used to assess risk of bias in included studies. Six trials involving 601 participants were included. All studies had high risk of performance bias. Three studies had an unclear risk of selection bias. Postoperative coffee consumption reduced time to first defecation (mean difference (MD), −9.98 hours; 95% CI, −16.97 to −2.99), time to first flatus (MD, −7.14 hours; 95% CI, −10.96 to −3.33), time to first bowel sound (MD, −4.17 hours; 95% CI, −7.88 to −0.47), time to tolerance of solid food (MD, −15.55 hours; 95% CI, −22.83 to −8.27), and length of hospital stay (MD, −0.74 days; 95% CI, −1.14 to −0.33). Benefits increased with increasing complexity of the procedure. None of the included studies reported adverse events associated with coffee consumption. Postoperative coffee consumption is effective and safe for enhancing the recovery of gastrointestinal function after abdominal surgery.
Highlights
Coffee is believed to prevent postoperative ileus
Of the nine studies that potentially met the review inclusion, six studies were included after reviewing the full texts involving 601 participants (Supplementary Table S1)
The findings of this study found no significant differences in the recovery of gastrointestinal functions after decaffeinated coffee consumption in terms of time to first defecation (MD, −1.27 hours; 95% confidence intervals (CI), −3.95 to 1.42), time to first flatus (MD, −1.90 hours; 95% CI, −4.33 to 0.54), and time to first audible bowel sound (MD, −0.80; 95% CI, −3.26 to 1.65) when compared to the control group[17]
Summary
Coffee is believed to prevent postoperative ileus. This systematic review and meta-analysis was undertaken to determine the effectiveness of coffee consumption in stimulating gastrointestinal function after abdominal surgery. Postoperative coffee consumption is effective and safe for enhancing the recovery of gastrointestinal function after abdominal surgery. Factors associated with an increased risk of POI following abdominal surgery include colorectal surgery, open abdominal surgery, emergency operations, prolonged operative time, amount of opioid analgesic use, longer nasogastric catheter use, and smoking history[1,3,4]. The second phase of POI, which typically occurs 3–4 h after operation, is mediated through the inflammation process caused by the release of pro-inflammatory cytokines and chemokines This inflammatory response activates the phagocytes residing throughout the gut to release nitric oxide and prostaglandins which reduce bowel mobility by inhibiting www.nature.com/scientificreports/. The use of a crystalloid solution can result in intestinal edema and stretching Common anesthetic agents such as halothane, enflurance, and atropine prolong gastric emptying times which increase risks of postoperative nausea and vomiting. Coffee consumption trends to reduce mortality[6]
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