Abstract
Purpose: Subchondral bone contributes to osteoarthritis(OA) progression. These days, osteoclasts, which is one of the key players of bone resorption, in subchondral bone has attracted increasing attention in the pathogenesis OA. If OA and osteoporosis(OP) coexist in the same patient, it is expected that the osteoclasts in subchondral bone could increase more and aggravate the OA pathology. But it is unclear whether knee OA progression are affected by presence or absence of OA and OP. The purpose of this study was to investigate the additional effect of postmenopausal OP caused by ovariectomy on the knee OA pathology, particularly focusing on histological OA progression in a medial meniscectomy induced OA rat model.
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