Effect of Post-Ischemic Adaptation Management on Myocardial Perfusion Injury in Patients Treated with Acute Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction

Abstract

To investigate the effect of post-ischemic adaptation on myocardial perfusion injury in patients with ST segment elevation myocardial infarction by percutaneous coronary intervention. 80 patients were selected and divided into observation group (receiving treatment, 46 cases) and control group (without treatment, a total of 34 cases) and then two groups of patients were compared with serum free oxygen radicals (lipid peroxide, nitric oxide, hydroxyl), detection of stress (superoxide dismutase, glutathione peroxidase, malondialdehyde products, advanced oxidation protein products, major adverse cardiac events) difference rate and follow-up period of myocardial reperfusion injury after operation. Compared with before treatment, the two groups of patients after 8 h, nitric oxide, hydroxyl, lipid peroxide at superoxide dismutase and advanced oxidation protein products decreased, glutathione peroxidase and malondialdehyde increased, were statistically significant (all p<0.05); 8 h after the operation time, the observation group lipid peroxide, nitric oxide, hydroxyl, superoxide dismutase, advanced oxidation protein products were lower than the control group, glutathione peroxidase malondialdehyde were higher than that of control group, were statistically significant (all p<0.05); the control group of patients after reperfusion injury incidence rate (17.65 %) was significantly higher than the observation group (6.52 %), comparison between groups was statistically significant (χ2=1.117, p<0.05); the incidence of major adverse cardiovascular events of control group during the follow-up period were 64.71 % which was significantly higher than that of observation group (36.96 %), the difference was statistically significant (p<0.05). Ischemic post conditioning can significantly improve the detection of oxygen free radicals and related stress products in patients with ST segment elevation myocardial infarction after percutaneous coronary intervention treatment, reduce the postoperative reperfusion injury and improve the prognosis of patients.