Abstract
The incorporation of [U— 14C]-D-glucose into lipid and protein of the brains of rats subjected to portocaval anastomosis has been studied from 2 to 20 weeks after the operation. It has been found that there is a reduction by about 30% of the labelling of protein, total lipid and of cholesterol in all experimental animals compared with controls. These findings are discussed in relation to the early astroglial disturbances after liver bypass and the later degenerative changes in terminal neurites that constantly occur in brain in this experimental preparation.
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