Abstract
Walker carcinosarcoma 256 was implanted in the middle or the left lobe of the liver of inbred Wister rats. Ligation of the portal vein branching to the lobe housing the tumor resulted in degeneration and atrophy of the implanted tumor. The challenge inoculation after tumor degeneration was rejected more than two times as rapidly as the allograft. The enhanced host resistance through activation of anti-tumor resistance by ligating the portal branch may be responsible for the suppression of the metastasis. The effect of portal branch ligation is mainly due to the interruption of the portal blood supply to the corresponding lobe, but also may be attributed to the activation of the anti-tumor resistance of the host.
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