Abstract
When two 9-day chick embryos, one with an adult spleen graft and the other with a 17-day embryo spleen graft on their chorioallantoic membrane, were joined with paraffin but separated by a membrane filter with a pore size of 0.45 μ or 0.10 μ respectively, the mean weight of the embryonic spleen graft, after seven more days of incubation, was three times greater than the mean weight of the embryonic spleen grafts in the control pairs which received no adult chicken spleen. Similar results were obtained when the embryonic spleen grafts were obtained from 13-day embryos and grafted on the 13th day of incubation. The mean weight of host spleen of the partner with the embryonic spleen graft was not greater than that in the control pairs. These experiments show that the adult spleen graft was able to stimulate growth of the embryonic spleen graft across thick membrane filters (120–150 μ) with the pore sizes as small as 0.10 μ. The differential stimulation between the 13-day embryonic spleen graft and the 13-day host spleen suggests that the response is not age-dependent.
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